https://www.neuro-adx-lab.com/tags/fmri/FMRIHugo Blox Builder (https://hugoblox.com)en-usMon, 01 Jan 2024 00:00:00 +0000https://www.neuro-adx-lab.com/media/logo_hu_9de78bf642a435bd.pnghttps://www.neuro-adx-lab.com/tags/fmri/https://www.neuro-adx-lab.com/projects/addict-response/Mon, 01 Jan 2024 00:00:00 +0000https://www.neuro-adx-lab.com/projects/addict-response/<h2 id="project-overview">Project Overview</h2> <p>ADDICT-RESPONSE is an FCT-funded research project examining how impairments in response inhibition — the ability to stop or override prepotent behavioral responses — contribute to the development and maintenance of addictive behaviors. Using a multimodal approach combining neuroimaging, psychophysiology, and behavioral paradigms, the project aims to characterize the neurocognitive profile of inhibitory control deficits in addiction and their role in treatment outcomes.</p> <h2 id="research-questions">Research Questions</h2> <ul> <li>How do deficits in response inhibition differ across substance use disorders?</li> <li>What are the neural correlates of impaired inhibitory control in individuals with alcohol use disorder?</li> <li>Do inhibitory control deficits predict relapse following treatment?</li> <li>Can targeted cognitive training improve inhibitory control and treatment outcomes?</li> </ul> <h2 id="methodology">Methodology</h2> <h3 id="neuroimaging">Neuroimaging</h3> <ul> <li><strong>fMRI</strong>: Task-based imaging during Go/No-Go and Stop-Signal paradigms</li> <li><strong>Resting-state fMRI</strong>: Functional connectivity analyses of inhibitory control networks</li> <li><strong>EEG</strong>: High temporal resolution measures of neural inhibitory processes</li> </ul> <h3 id="behavioral-assessment">Behavioral Assessment</h3> <ul> <li>Stop-Signal Task and Go/No-Go paradigms</li> <li>Alcohol and substance cue-reactivity protocols</li> <li>Ecological momentary assessment of craving and inhibitory failures</li> </ul> <h3 id="clinical-sample">Clinical Sample</h3> <ul> <li>Adults with alcohol use disorder in outpatient treatment</li> <li>Matched healthy control participants</li> <li>Longitudinal follow-up at 3, 6, and 12 months post-treatment</li> </ul> <h2 id="funding">Funding</h2> <p>Funded by the Portuguese Foundation for Science and Technology (FCT), this project supports research activities at the William James Center for Research, ISPA–Instituto Universitário.</p>