ADDICT-RESPONSE: Neural and Cognitive Mechanisms of Response Inhibition in Addiction
Jan 1, 2024·
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1 min read
Dr. Jorge Martins
Dr. Sara Félix
Project Overview
ADDICT-RESPONSE is an FCT-funded research project examining how impairments in response inhibition — the ability to stop or override prepotent behavioral responses — contribute to the development and maintenance of addictive behaviors. Using a multimodal approach combining neuroimaging, psychophysiology, and behavioral paradigms, the project aims to characterize the neurocognitive profile of inhibitory control deficits in addiction and their role in treatment outcomes.
Research Questions
- How do deficits in response inhibition differ across substance use disorders?
- What are the neural correlates of impaired inhibitory control in individuals with alcohol use disorder?
- Do inhibitory control deficits predict relapse following treatment?
- Can targeted cognitive training improve inhibitory control and treatment outcomes?
Methodology
Neuroimaging
- fMRI: Task-based imaging during Go/No-Go and Stop-Signal paradigms
- Resting-state fMRI: Functional connectivity analyses of inhibitory control networks
- EEG: High temporal resolution measures of neural inhibitory processes
Behavioral Assessment
- Stop-Signal Task and Go/No-Go paradigms
- Alcohol and substance cue-reactivity protocols
- Ecological momentary assessment of craving and inhibitory failures
Clinical Sample
- Adults with alcohol use disorder in outpatient treatment
- Matched healthy control participants
- Longitudinal follow-up at 3, 6, and 12 months post-treatment
Funding
Funded by the Portuguese Foundation for Science and Technology (FCT), this project supports research activities at the William James Center for Research, ISPA–Instituto Universitário.